Clinical Fact Sheet on Beta 1, 3d Glucan
Beta-1, 3-D glucan is derived from the cell walls of Saccharomyces cerevisiae, a baker's yeast. The beta glucan molecule is a polybranched, polyglucose. Beta-1, 3-D glucan is the backbone of this molecule. Approximately 85% of the beta glucan molecule is the 1,3 glucose, 3-5% are the 1-6 glucose side chains. Effectiveness is greatly reduced if the active 1,3 glucose falls below 80% purity. There has been no peer reviewed studies that has shown any beneficial effects for any Beta Glucan product that falls below 80% purity.
Part used: Carbohydrates that have the proteins and fats removed. It is a complex polysaccharide molecule consisting of a chain of glucose molecules that is highly purified.
Intended Indications: Biological Response Modifier.The systemic effect can be described as non-specific immune modulation combined with free radical scavenging activity. There have been many studies from well know Universities (Harvard, Tulane, Louisville) demonstrating the immune-enhancing effects of Beta-1, 3-D glucan.In addition to these immune system-related effects, beta glucans have been noted to assist the body in lowering cholesterol levels, promoting rapid wound healing, protecting against radiation exposure, and inhibiting viral, staphylococcal, pseudomonas and candida pathogenicity. There are over 2000 papers on beta glucan in the scientific literature; many of them animal as well as human studies that suggest that it might be useful in fighting cancer. No contraindications have been reported regarding combining beta glucan with chemotherapy or radiation therapy. Listed in the FDA's "generally recognized as safe" category, beta glucan has no known contraindications, side effects, or toxicity.
People, who have impaired immunity from many causes including chronic fatigue, fibromyalgia, chronic stress, or persistent viruses, can take beta glucan to heighten their defenses.Those who suffer from chronic degenerative disorders, i.e. diabetes mellitus or chronic inflammation may also benefit from beta glucan's immune enhancement. Those habitually exposed to environmental pollutants, UV radiation, and other toxins could benefit from the antioxidant effects and potent free-radical scavenger effects. Amateur and professional athletes may derive health-building benefits from beta glucan.
Mode of Action: The beta glucan modulates the macrophage, which is the oldest and most consistently preserved immunologically competent cell known. All the functions, including phagocytosis (ability to engulf foreign cells and particles), release of certain cytokines (intercellular "fax messages") IL-1, IL-6, GM-CSF, interferon and the processing of antigens are improved. Macrophages are involved in every day detoxifying processes, intestinal flora maintenance, anti-infective and anti-tumor protection and maintenance of overall health integrity. Beta glucan taken orally differs from other food substances. This type of glucan is acid resistant so it passes the stomach virtually unchanged. Macrophages in the intestinal wall make contact with the beta glucan particles. Activation of these cells follows and later, they are able to travel back to the local lymph nodes as part of their natural antigen-presenting function, release cytokines and induce systemic immune activation. Single dose studies of beta glucan indicate that macrophage function may peak in 72 hours.
Dosage: "As a preventative supplement, most people claim to see great results taking two 100 mg capsules a day, as the bottle label describes. The 500mg bottle also calls out for 2 capsules a day. For those with serious conditions studies have shown a much larger dose maybe necessary. Consult a nutritionist or others skill in the health field.
Results are seen in little as two weeks or as long as two months or more. Every person is unique and so is every immune system. Talk to you doctor if you have any questions. The Information on this site can be easily downloaded and printed out. This will allow you to give this information to your doctor so he/she can make an informed decision.
Most people take the product on an empty stomach first thing in the morning, with water, and do not eat for at least an hour.
- Specificity of membrane complement receptor type three (CR3) for beta-glucans. Ross GD, Cain JA, Myones BL, Newman SL, Lachmann PJ. Complement. 1987;4(2):61-74. PMID: 3040332. Ross GD, Vetvicka V.Clin Exp Immunol. 1993 May;92(2):181-4. ;Role of complement receptor type three and serum opsonins in the neutrophil response to yeast. Cain JA, Newman SL, Ross GD. Complement. 1987;4(2):75-86. PMID: 3040333; Complement. 1987; Kournikakis B, Mandeville R, Brousseau P, Ostroff G. MedGenMed. 2003 Mar 21;5(1):1. PMID: 12827062; Beneficial effect of enhanced macrophage function in the trauma patient. Browder W, Williams D, Pretus H, Olivero G, Enrichens F, Mao P, Franchello A. Ann Surg. 1990 May;211(5):605-12; discussion 612-3. PMID: 2111126