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IL-2 Production (Interleukin 2) and Immune Support

Il 2 Production and Immune Support

Interleukin-2 (IL-2) refers to a regulatory peptide necessary for growth and differentiation of large granular lymphocytes and antigen-specific T lymphocytes. It can also be described as a T-cell-derived cytokine that is vital in regulating the growth and differentiation of B-Cells, T-Cells, glioma cells, natural killer cells and monocyte-linked cells after specific interaction with its receptors. The human IL-2 comprises of a 133-anmino acid polypeptide and a molecular mass of about 15-18 kDA[1].

IL-2 Production and Immune Support

Generally, manufactures totally disregard all these essential immune support indicators, in this case the production of IL-2, or perform 'in-house' evaluations and apply the final results as evidence their goods generate proper immune support results, yet they never test them against other products or ina independent setting. To be able to determine whether an product genuinely delivers actual tangible outcomes it must be reviewed against other products, further it needs to be carried out in an atmosphere that's separate from the manufacturer to remove questions about the results. IL-2 production, as described above and detailed further below play a significant role in immune support. Here are the other more significant components and processes of the immune system;

  • Nitrite Oxide Production; plays a important role in the immune system in which components produce nitrite oxide for the purpose of killing bacteria.
  • Phagocytosis; is a major function of immune support. It is the starting point of the immune systems attack on a invader...
  • Superoxide Anion; is a compound that has several functions. It is utilized by the immune system to kill foreign pathogens and microorganisms.

In the independent peer reviewed study "B1,3-Glucan: Silver Bullet or Hot Air; Vetvicka. Open Glycoscience, 2010, 3, 1-6" Beta Force Beta Glucan material was independently tested against over sixteen other more popular immune support supplements for Interleukin-2 production and the other listed processes and compounds listed above. Below you will see the graphed results of the study as well as a detailed explanation of why Interleukin-2 production plays such an important role in immune support.

Interleukin-2 falls in the category of biologic response modifiers (BRMs). BRMs are known for their role in modifying the response of the body to cells. IL-2 falls in the cytokines family which acts mainly by facilitating communication between the body immune system and various cells[2].

Il-2 Production
Sixteen of the most popular immune support products were tested for Phagocytosis. Beta Force beta glucan provided highest response[6].

The body's first response to pathogens is defined by the immune response. The immune response system acts like an alarm by signaling the body that something harmful has entered the body. This response is usually triggered by the body's immune system which comprises of the cells that fight infection within the body. The body's immune system is always alert against disease-causing bacteria, fungi and viruses. It protects the body from any unfamiliar substances/elements including malignant cells. It sees such cells as harmful. Once the detection is made, the immune system responds by sending fighter cells (the white blood cells) or forms antibodies to destroy these pathogenic substances. Lymphocytes, types of white blood cells, make IL-2. Interleukin-2 is usually made in small quantities by the body and activates the immune system to assist the body fight malignant cells.

During the immune response, antigen binding to T-cell receptor (TCR) stimulates the IL-2 secretion as well as IL-2 receptors (IL-2). The interaction between IL-2 and IL-2R is what brings growth and differentiation of cytotoxic T-cells. This underscores the role played by IL-2 in the development of immunologic memory of T-cell. IL-2 is essential in the maintenance of regulatory T-cells (Treg) and the CD4+ cell differentiation into effector T-cells subsets after antigen-mediated activation. IL-2 is usually presented in soluble form or in a form that is bound to dendritic cells together with an extracellular matrix[3].

Due to the essential role played by IL-2 in controlling immune response by maintaining functional Treg, new ideas have risen bringing in the potential of interleukin-2 as a therapeutic tool in autoimmune related issues. According to the European Journal of Immunology IL-2 complexes could improve autoantibody-mediated autoimmunity[4].

Beta Glucan

The T-cells are among the most important elements that make up the human immune system. Its role in direct destruction of cancerous or infected cells is great. Furthermore, T-cells act as the control hub for the rest of Innate and Acquired immune system[5]. Several other types of cells including macrophages, B-cells and NK cells are essential during the effector phase of immune response. It is this linkage that defines the important role of IL-2 in immune system support and function since it facilitates or boosts proliferation (colonal expansion) as well as differentiation of extra cells.

IL-2 plays an important role in human body and is therefore an important and an integral factor of the immune response system.

Beta Force Beta Glucan provided the highest response rate then it closest competitor[6] in IL-2 production. It also provided the best results for the other following immune support responses;

beta glucan product order link immune support supplements test
  1. http://en.wikipedia.org/wiki/Interleukin_2
  2. http://www.medical-library.net/content/view/846/9/
  3. http://faculty.ucc.edu/biology-potter/Immunity.htm
  4. Dooms H, Abbas AK., Revisiting the role of IL-2 in autoimmunity., Eur J Immunol. 2010 Jun;40(6):1538-40.
  5. http://www.niaid.nih.gov/topics/immunesystem/immunecells/pages/tcells.aspx
  6. B1,3-Glucan: Silver Bullet or Hot Air; Vetvicka. Open Glycoscience, 2010, 3, 1-6