Phagocytosis is a process by specialized cells called phagocytes, which remove foreign bodies and thus fight infection. Macrophages can perform phagocytosis on bacteria, dead tissue cells, small mineral particles and other objects.
In an independent study conducted by a Canadian biopharmaceutical company, normal human volunteers were dosed for 10 consecutive days with one 250 milligram-capsule containing Beta 1,3-D Glucan. The subjects were monitored for 30 days.
Beta 1,3-D Glucan was safe and well tolerated, as evidenced by the lack of significant changes in key blood and liver enzymes. It also significantly increased phagocytic capacity-the ability of the innate immune cells to eat and destroy foreign intruders. After 10 days of treatment Whole Particulate Beta 1,3-D Glucan had increased the percentage of immune cells able to phagocytose one particle from 63.8% to 83.2% (P< .05) .
The number of highly phagocytic cells -those consuming at least three particles -increased from 37.3% to more than 50% (P< .05). These results show that taking Beta 1,3-D Glucan enhanced the human immune system to defend the body against a challenge.
Beta 1,3-D Glucan is the only yeast-based beta glucan that has been shown scientifically to enhance immune function in humans. "The results are consistent wit h the biological activity of... Beta 1,3-D Glucan observed in numerous animal studies," said Rosemonde Mandeville, M.B. ChB. Ph.D., President and Chief Scientific Officer of Biophage Pharma.
In addition, researchers also found that Beta 1,3-D Glucan increased plasma cytokines INF -y and TNF -a, which play an important role in regulating the body's immune response. There was no significant increase in cytokine IL-1 which can cause fever, chills and muscle aches associated with other immune- enhancing supplements.
These results are similar to those obtained from a 1999 study published in the American Journal of Clinical Nutrition in which men consumed 15 grams of Beta 1,3-D Glucan-60 times the recommended daily dosage for 12 weeks without adverse effects.Whole glucan particulate Beta 1, 3-D Glucan is not a treatment for any disease or condition. Beta Glucan is an immunomodulator that has been shown to support immune system function.
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