An apple a day may keep the doctor away, but results of a recent human clinical study suggest far better results may be obtained with a dietary supplement and functional food ingredient called Beta Glucan..

Beta 1,3-D Glucan is a patented carbohydrate extracted and highly purified from the cell walls of Baker's yeast. Produced and manufactured totally right here is the good old USA, a whole glucan particulate Beta 1,3-D Glucan is the active ingredient in our 100 mg capsules, our 500 mg capsules, our BetaXanthinTM and our Formula III lotion. All of these products help to support immune function.

In an independent study conducted by a Canadian biopharmaceutical company, normal human volunteers were dosed for 10 consecutive days with one 250 milligram-capsule containing Beta 1,3-D Glucan whole glucan particles. The subjects were monitored for 30 days. This human clinical showed that the Beta Glucan was safe and well tolerated, as evidenced by the lack of significant changes in key blood and liver enzymes. It also significantly increased phagocytic capacity (see chart)—the ability of the innate immune cells to eat and destroy foreign intruders.

On day ten (10) of the study, our Beta Glucan increased the percentage of immune cells able to phagocytose one target particle from 63.8% to 83.2% (P< .05). The number of highly phagocytic cells—those consuming at least three particles—increased from 37.3% to more than 50% (P< .05). These results show that taking Beta Glucan enhanced the human immune system to defend the body against a challenge.

“To my knowledge, this is the only Beta Glucan that is yeast-based that has been shown scientifically to enhance immune function in humans,” said A.J. Lanigan. A.J. Lanigan is part owner of the US manufacturing facility and company which owns patents protecting all of his Beta Glucan products and all use of yeast beta glucans in dietary supplements and functional foods.

“The results are consistent with the biological activity of Beta 1,3-D Glucan observed in numerous animal studies,” said Rosemonde Mandeville, M.B. ChB. Ph.D., President and Chief Scientific Officer of Biophage Pharma. In addition, researchers also found that Beta 1,3-D Glucan increased plasma cytokines INF-y and TNF-a, which play an important role in regulating the body’s immune response. There was no significant increase in cytokine IL-1, which can cause fever, chills and muscle aches associated with other immune-enhancing supplements.

Beta 1,3-D Glucan was safe and well tolerated, as evidenced by the lack of significant changes in key blood and liver enzymes. It also significantly increased phagocytic capacity-the ability of the innate immune cells to eat and destroy foreign intruders.

Beta 1,3-D Glucan is the only yeast-based beta glucan that has been shown scientifically to enhance immune function in humans.

"The results are consistent wit h the biological activity of... Beta 1,3-D Glucan observed in numerous animal studies," said Rosemonde Mandeville, M.B. ChB. Ph.D., President and Chief Scientific Officer of Biophage Pharma who reviewed the results of the immune boosting capabilities of Beta 1, 3d glucan.

In addition, researchers also found that Beta 1,3-D Glucan increased plasma cytokines INF -y and TNF -a, which play an important role in regulating the body's immune response. There was no significant increase in cytokine IL-1 which can cause fever, chills and muscle aches associated with other immune- enhancing supplements.

These results are similar to those obtained from a 1999 study published in the American Journal of Clinical Nutrition in which men consumed 15 grams of Beta 1,3-D Glucan-60 times the recommended daily dosage for 12 weeks without adverse effects.

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